The Dream currently holds the WBC, WBA, WBO and IBF titles but is set to take a huge risk and put them on the line alongside his unbeaten record in Las Vegas.
The 24-year-old boasts a 29-0-0 record but will face the toughest challenge of his career against one of the best pound-for-pound fighters.
Lomachenko has been the world champion across three weight classes and is looking to win back the titles he lost in 2020 against Teofimo Lopez.
Date: Saturday, May 20
Start time: 10 p.m. ET / 3 a.m. BST
Main event ringwalks (approx): 12 a.m. ET / 5 a.m. BST
The main card is set to get underway at 10 p.m. ET / 3 a.m. BST with the main event ringwalks scheduled for 12 a.m. ET / 5 a.m. BST. Viewers in the U.S. will be able purchase the fight on ESPN+ PPV. The fight will take place at the MGM Grand Garden Arena in Las Vegas.
What has been said?
Haney: "Lomachenko is a good fighter and future Hall of Fame candidate.
"I take nothing away from him or what he has done in the sport of boxing.
"I can't wait for this fight. I know Lomachenko has an extremely high boxing IQ, and I will show the world on May 20 that I'm the best fighter on the planet.
"I'm ready to defend my undisputed title in devastating fashion."
Lomachenko: "My goal is to become the undisputed lightweight champion, and Devin Haney is the man with the belts.
"I respect his boxing IQ and am excited for this challenge."
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